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As doctors go virtual, pandemic turbocharges telemedicine

By - Jun 02,2020 - Last updated at Jun 02,2020

Doctors across the world have moved consultations online (AFP photo)

PARIS — Will visiting the doctor ever be the same again? 

In a matter of weeks, the coronavirus pandemic sparked a technological revolution in healthcare systems across the world that might otherwise have taken years. 

Spurred on by fears of contagion in wards and waiting rooms, many health practitioners are replacing the face-to-face meetings that have always underpinned general practice, with patient consultations by telephone and online video apps. 

Some of the most radical changes have been in primary healthcare, where doctors have often faced shortages of protective equipment, but specialists in everything from mental health to eye care have also turned to technology to treat patients at a distance.

“General practice has undergone significant changes in the way GPs and our teams have delivered patient care during the pandemic — and the speed in which these changes were implemented has been remarkable,” Professor Martin Marshall, chair of Britain’s Royal College of GPs told AFP. 

As the virus spread, health authorities in the UK, Europe and elsewhere updated guidance on everything from data protection to how to build trust remotely. 

The United States rolled back restrictions on access to telemedicine, and eased privacy regulations to allow people to use platforms like Skype and FaceTime. 

“People are now seeing this model, which we thought would take years and years to develop. And it’s probably been accelerated by a decade,” Chris Jennings, US policy consultant and former White House health care adviser told STAT news recently.

Globally, 58 per cent of surveyed countries are now using telemedicine, the World Health Organisation (WHO) said on Monday, adding the figure was 42 per cent among low income nations.

Layla McCay, a director at the NHS Confederation representing British healthcare services, told AFP that most of the UK’s 1.2 million daily face-to-face primary care consultations were done remotely “in the space of weeks”.

But there were challenges. 

“My first video consultation was a mess. Builders were drilling, the microphone failed, a colleague walked in, and lockdown was imminent,” Camille Gajria, a doctor and clinical teaching fellow at Imperial College London, told the British Medical Journal. 

She said teleconsultations can be efficient but warned of “cognitive bias” — a doctor, for example, might assume that a child playing in the background is the one being discussed.

There are also concerns that vulnerable patients might find it difficult to talk about mistreatment at home, while elderly people could struggle to navigate unfamiliar technology.

 

Remote medicine

 

Telemedicine may seem like a product of the internet age, but it has been around for decades, developing alongside communication technology. 

One big leap came during the space race of the 1960s, when scientists worried about the effect of zero gravity on the human body. Would it impede blood circulation or breathing?

To find out, both the US and Soviet Union conducted test flights with animals hooked up to medical monitoring systems that transmitted biometric data back to scientists on Earth. Later, longer missions meant astronauts needed systems that could diagnose and help treat medical emergencies. 

NASA went on to develop terrestrial telemedicine, including a project to provide healthcare to the isolated Tohono O’odham reservation in Arizona, as well as disaster response in the 1985 Mexico City and 1988 Armenia earthquakes. 

While the coronavirus pandemic has driven sweeping changes in the way many people see their local doctor, it has also highlighted the role telemedicine can play in connecting clinicians with remote communities. 

In India, which has just 8.6 medical workers per 10,000 people according to 2018 WHO figures, the majority of doctors are concentrated in urban centres, while some 70 per cent of people live in rural areas. 

Ayush Mishra, founder of the telehealth provider Tattvan, said this means people outside bigger towns are often forced to seek medical advice from overstretched or ill-qualified practitioners. 

His business, one of a growing number of telehealth providers in India, operates 18 clinics, mostly ATM-style booths that are manned by a medical assistant who can take vital measurements and linked with doctors in private hospitals in larger towns. 

The firm languished in a legal grey zone for years until the coronavirus crisis spurred the government into broadening regulatory approval for virtual consultations. Now he hopes to open hundreds of clinics around the country. 

Mishra traces his enthusiasm for telemedicine to a horrific motorbike accident when he was a biomedical engineering student in the northern city of Jaipur. 

Severely injured, he was driven ten hours to his hometown in Uttar Pradesh, before falling into a coma as a local doctor performed surgery. 

His family was overwhelmed by “panic” until his father spoke by telephone to a surgeon at a hospital in Delhi, enabling them to arrange treatment in the city. 

Mishra lost his leg, but told AFP the experience inspired him to want to equalise medical access for people in smaller towns. 

“You need to be able to offer this access — it’s a human right,” he said. 

 

Not going back?

 

Internet-connected thermometers, pulse oximetres to measure oxygen levels, and smart devices that monitor vital signs are all widening the scope of what is possible in remote medicine.

In an April article for JAMA neurology, experts from The Netherlands and US said telemedicine could be a useful tool for in-home training, such as activities for survivors of stroke. Patients, they noted, could be monitored via sensors in watches or phones. 

“We hope that this current COVID-19 crisis will soon be resolved. However, it is as the old saying goes: ‘never waste a good crisis’,” they said. 

“Telemedicine for chronic neurological disorders should become part of the new normal rather than the exception.” 

Marshall said there are still many routine procedures — vaccinations, blood tests and physical examinations — that cannot be done remotely.

“Those living with multiple conditions and other complex health needs really benefit from seeing their doctor in person — and this is helpful for the GP, as well,” he said. 

But he added that research supports the use of remote consultations for patients with simple conditions, or who have “transactional” needs like a repeat prescription.

Many say they want at least some of the changes to stay. 

“It has certainly turbocharged the digital transition nationally,” said McCay of the NHS Confederation.

“Lots of feedback from our members shows the culture has fundamentally changed, and clinicians who were perhaps previously resistant to digitisation are now realising its benefits.”

“We can’t go backwards,” she added. 

Ford F150 Lariat Sport Special Edition: A faithful foul-weather friend

By - Jun 01,2020 - Last updated at Jun 01,2020

Photos courtesy of Ford

America’s best selling truck for over four decades and a staple work, play and family vehicle in North America and the Middle East; to say that the Ford F150 is familiar is an understatement. A rugged and practical everyman truck brimming with technology, capability and creature comforts, the F150’s many merits — and large truck vices for certain markets — are well established. Inspiring admiration during many previous test drives, it has never been as convincing as earlier this year, during several days dominated by torrential rains and flooded roads.

Delivered on a sunny first day gleaming from a fresh wash and in an almost matte grey silver finish that reminded one of its unique lightweight military grade aluminium body, the F150 also never looked as good as it did in Lariat Sport specification with Special Edition appearance package; bar of course the extra special skunksworks Raptor variant. Perfectly proportioned with its four-door Supercrew body, near equal height-to-width ratio and with just the right bulging to its wheel-arches to visually reduce the vertical distance to its bonnet, this F150 has distinctly more dramatic presence than usual.

 

Dramatic daily driver

 

With squared off features, sharp straight cut lines, twin-dome bonnet, vast upright grille and its appealing aesthetic proportions, the F150 has an unmistakably assertive presence that is full of tension and restraint, unlike some trucks’ overstated, almost caricature-like take on aggression. Both more dramatic and low key next to other F150 trim levels’ liberal use of chrome, the Special Edition body colour and black accents lend a more dramatic appeal. Black alloys and running boards, and its body colour grille outline, mesh and faux inlets bisecting its big headlights worked particularly well at bringing out the F150’s almost sinister side.

Decked out with bonnet-top and side decals that lend a sportier aesthetic and reduce the F150’s visual heft, the Sport part of this Lariat’s designation is nonetheless only an appearance package. However sportier they might “feel”, the Special Edition “go-faster” graphics don’t make the F150 go any faster. That said, the Lariat’s Sport’s twin-turbo direct injection 3.5-litre V6 Ecoboost engine provides plenty of “fast” as is. Down-sized but more efficient next to the F150’s more traditional naturally-aspirated 5-litre V8 Coyote engine, the Ecoboost is the more effective “real world” daily drive engine.

 

Bountiful boost

 

Offered in two states of tune across the F150 range, the Lariat line receives the standard 3.5 Ecoboost, developing 375BHP at an easily accessible 5,000rpm and enormous 470lb/ft torque peaking at 3,500rpm, but with much of that available throughout a broad rev band. Spooling up swiftly from standstill and with a comparatively low in-class weight due to its aluminium body, the F150 Lariat Sport proved quick and eager throughout, pouncing from standstill to 100km/h in an estimated 6-seconds and overtaking with effortless versatility, whether when cruising or at higher speeds.

Eager unleashing its power, the F150’s climb to its top end peak is underwritten by a deep indefatigable reservoir of torque allowing for urgent response and confident cruising. Meanwhile, its slick, quick and smart shifting 10-speed automatic gearbox provides a broad range of closely spaced ratios to best utilise available output for performance and economy. Built to haul and tow heavy loads of up to 921kg and 5,760kg respectively, the F150 can be driven in regular high or low gear ratio four-wheel-drive for escalating levels of extreme loads, conditions, inclines and terrain.

 

Come rain or shine

 

However, when the storms came on the second day, the F150 coped perfectly well driving in its more economical rear-wheel-drive-mode in almost all circumstances, where plenty of traction and grip were available. Driven under such conditions — and the occasional dry spell — the F150 would turn into corners in a tidy manner with restrained body lean and reassuring front grip. Direct and well-weighted, the F150’s electric-assisted set-up well translates Ford’s usual knack for making sporty and connected steering feel for service in a truck.

Driven during a week of intensive test drives and intense weather, the Lariat Sport proved to be the most utilitarian, and took on the role of running reconnaissance. Comfortable, spacious and very well-equipped yet ruggedly luxurious, the tough, highly capable and trustworthy F150 served to scout “safe” routes before one dared venture out in more expensive, less rugged and “precious” vehicles. With it excellent 238mm ground clearance, four-wheel-drive and generous 25.5° approach 21° break-over and 26° departure angles, the F150 effortlessly traversed flooded streets where even some SUVs couldn’t go under prevailing conditions.

 

Rugged comfort

 

One of the best riding and handling in the large body-on-chassis and live axle rear suspension truck segment, the F150’s low in-class weight and near even weight distribution lend it comparatively keen handling, and it feels balanced through corners with good rear grip owing to its long wheelbase. Meanwhile, a brake-based torque vectoring system enhances cornering agility and stability. Stable at speed and more settled over lumps, bumps and imperfections, the F150 feels more vertically buttoned down than most rivals and is probably about as smooth and comfortable as trucks get in this segment.

Winner of the 2020 Middle East Car of the Year awards’ best Full-Size Truck category, the F150 is hugely spacious inside, especially with the absence of a sunroof, as driven in Lariat Sport spec, and comfortably seats five, with easy cabin access, voluminous storage spaces and advanced and extensive infotainment systems. Seating is comfortable, supportive and well adjustable, with dual tone upholstery in mid-range Lariat Sport trim. Front and side visibility is good, while big side mirrors and a 360° camera aid reversing and manoeuvrability. Standard and optional equipment meanwhile include a slew of advanced driver assistance safety systems.

TECHNICAL SPECIFICATIONS

  • Engine: 3.5-litre, all-aluminium, twin-turbo, in-line V6-cylinders
  • Bore x stroke: 92.5 x 86.7mm
  • Compression ratio: 10.5:1
  • Valve-train: 24-valve, DOHC, variable valve timing
  • Gearbox: 10-speed automatic, four-wheel-drive, low ratio transfer case, optional locking rear differential
  • Gear ratios: 1st 4.696; 2nd 2.985; 3rd 2.146; 4th 1.769; 5th 1.52; 6th 1.275; 7th 1.0; 8th 0.854; 9th 0.689; 10th 0.636; R 4.866
  • Axle ratio options: 3.31:1 or 3.55:1
  • Power, BHP (PS) [kW]: 375 (380) [280] @5,000rpm
  • Specific power: 107.2BHP/litre
  • Torque, lb/ft (Nm): 470 (637) @3,500rpm
  • Specific torque: 182.2Nm/litre
  • 0-100km/h: approximately 6-seconds (estimate)
  • Top speed: 170km/h (estimated, electronically governed)
  • Minimum fuel requirement: 91RON
  • Length: 5,890mm
  • Width: 2,030mm
  • Height: 1,961mm
  • Wheelbase: 3,683mm
  • Track: 1,717mm 
  • Overhang, F/R; 960/1,247mm
  • Ground clearance: 238mm
  • Approach/break-over/departure angles: 25.5°/21°/26°
  • Seating: 5
  • Headroom, F/R: 1,036/1,026mm
  • Legroom, F/R: 1,115/1,108mm
  • Shoulder room, F/R: 1,694/1,674mm
  • Hip room, F/R: 1,588/1,644mm
  • Cargo bed height, length, width: 543, 1,705, 1,285-1,656mm 
  • Load floor height: 907mm
  • Cargo box volume: 1,495-litres
  • Fuel capacity: 98-litres
  • Kerb weight: approximately 2,225kg (estimate)
  • Payload: 921kg
  • Towing maximum: 4,854-5,760kg (depending on axle ratio)
  • Steering: Electric-assisted rack & pinion
  • Turning circle: 15.57-metres
  • Suspension, F/R: Double wishbones, coil springs/live axle, leaf springs
  • Brakes, F/R: Ventilated discs, 350 x 34mm/drum, 336 x 24mm
  • Brake calipers, F/R: Twin/single
  • Tyres: 275/55R20

Japanese bathhouses awash with post-lockdown customers

By - May 31,2020 - Last updated at May 31,2020

Public bathhouses in Japan are gradually reopening from virus lockdowns (AFP photo by Behrouz Mehri)

YOKOHAMA, Japan — Masazumi Kato sighed deeply as he lowered himself into a tub at a public bathhouse in a Tokyo suburb, enjoying a return to a Japanese tradition largely off-limits during the city's coronavirus lockdown.

With the lifting of a nationwide state of emergency over the virus, Japan's onsen — large bathhouses where patrons bathe naked in a series of warm pools and tubs — are gradually reopening.

And fans like 52-year-old Kato have few qualms about returning.

"I believe they are taking anti-virus measures, like chlorine," he told AFP as he soaked in an outdoor tub, with other naked men submerged in pools nearby.

"I trust them and I like to use this place," said Kato, a frequent patron of the Yumominosato facility in Yokohama, outside Tokyo.

The five-storey bathhouse is typical of the hugely popular onsen that dot the country.

It hosts a range of indoor and outdoor pools, usually with spring water and sometimes equipped with jets to massage pressure points or mineral-rich water said to offer health benefits.

The facility is also home to a restaurant, massage rooms, a comic book library and various relaxation rooms. For many Japanese an onsen trip is a day-long experience, with bathing punctuated by naps, massages and lunch.

But most large onsen shut their doors when the government declared a state of emergency in April, initially in Tokyo and a few other regions but the closures eventually expanded nationwide.

The government designated smaller bathhouses called sento — which in the past often catered to people with no bath at home — as essential businesses, allowing them to remain open.

They were asked to increase ventilation in closed areas, maintain distance between customers and wipe down areas that people touch, including lockers and door knobs.

 

Temperature checks, face masks

 

But Yumominosato was closed for around two months, and is now hoping it can convince customers it is safe to return.

Kato said he was not worried about the virus, despite the enclosed indoor spaces and impossibility of wearing a mask while in hot tubs.

"We already know how it transmits from a person to person and from objects to people. So you don't go out and touch everything in your sight," he said.

"I think individually I am taking the necessary measures."

Japanese infection experts have not specifically discouraged the use of public baths, though they have stressed that patrons should observe good hygiene practices and social distancing.

At Yumominosato, customers must now have their temperature checked before entering, and are asked to keep their distance in and out of the water.

They are also asked to wear face masks outside of bathing areas and use hand sanitiser located throughout the building.

 

'Feels great'

 

Before the pandemic, the facility regularly welcomed up to 1,000 people in a single day, and demand is now gradually picking up again, said manager Hiroshi Saito.

Five hundred customers visited in the first two days after it reopened.

"First and foremost, I am relieved," Saito told AFP.

"Of course the coronavirus is not completely gone. The possible second wave of infections is also something that is in people's mind. So we have increased our sanitation efforts... so that our guests can fully relax and really enjoy our facility."

And that is just what businessman You Sasaki was doing as he sat in an outdoor tub, enjoying the early summer sun and a gentle breeze.

"This feels good. Feels great," the 50-year-old said, in a tub set up with a television set for bathers to watch while they soak.

He said he had adhered to "stay home" calls during the emergency, but had been counting down to the reopening of onsens, as an aficionado who visited public baths three to four times a week before the coronavirus.

"The last time I came here was the end of March. The onsen is always special. It's hard to explain in words. Dipping in a large tub is just so relaxing," Sasaki said.

"This is part of our lives. I don't think you can separate us from this, the bath. It's true for me. It's true for every Japanese."

By Hiroshi Hiyama

Gilead is rotting

By - May 31,2020 - Last updated at May 31,2020

The Testaments

Margaret Atwood

London: Chatto & Windus: 2019

Pp. 419

“The Testaments” is the novel for which Margaret Atwood won the 2019 Booker Prize, jointly with Bernardine Evaristo. It is the sequel to “The Handmaid’s Tale”, Atwood’s dystopian novel about Gilead, a puritanical theocracy where women are prized only for their reproductive capacity, and otherwise systematically disempowered and abused.

Since its 1985 publication, “The Handmaid’s Tale” has had a rebirth in an acclaimed TV series and as a symbol of feminist resistance after the election of Donald Trump. Atwood was pleased with the TV series, not least because it “respected one of the axioms of the novel: no event is allowed into it that does not have a precedent in human history”, which makes the story all the more chilling. (p. 418)

Atwood was prompted to write “The Testaments” by readers’ questions about what happened after “The Handmaid’s Tale”, which ends inconclusively. In fact, one learns much more about Gilead in the new novel, how it was established by a coup against the US government; its spartan, war-time economy since fighting still rages in many areas; the rampant corruption in the ruling hierarchies from black market luxuries available only to the Commanders to widespread purges based on false witness; and the cover-up of murders, suicides, torture, paedophilia, and baby switching. Cruelty was always there, but in the beginning, there was idealism as well. Now, there are only power struggles and lies. “Beneath its outer show of virtue and purity, Gilead was rotting”. (p. 308)

Getting a more comprehensive picture of Gilead is a function of the narrators. As the title indicates, the first novel is told by a Handmaid, a nearly anonymous woman who stays in the house of a Commander and his Wife who cannot have children, until they acquire a child by virtue of her intercourse with the Commander. Per definition, the Handmaid is confined to the domestic sphere and acquires only limited knowledge of other goings-on via hearsay. 

In contrast, “The Testaments” has three narrators. The first, Aunt Lydia, is the most powerful woman in Gilead whose career attests to the often-repeated maxim: Knowledge is power. Originally a judge who was captured after the coup, she decides, after an initial round of torture, to cooperate with the Commanders. With intelligence and deviousness, she manoeuvres herself to the top of the women called the Aunts, who organise the women’s sphere in Gilead, subject only to the approval of a top Commander. They train the young women in their charge to be suitable Handmaids or Wives for the Commanders or, occasionally, Aunts, and discipline them harshly for any infraction. Behind-the-scenes, they participate in important decisions concerning what status women will have, who they will marry, etc. And, crucially, they are allowed a library.

Aside from outright torture, the main tool of women’s disempowerment in Gilead is the edict forbidding them to learn to read and write. Ironically, in a state supposedly embodying the will of God, the Bible is kept under lock and key, accessible only to the Aunts, who are thus able to propagate their own interpretations. 

Harbouring a desire for revenge for her forced conversion, Aunt Lydia’s idea of knowledge encompasses knowing others’ dirty secrets in order to manipulate them. Will she use her knowledge to bring Gilead down?

The other two narrators are young women in the process of becoming Aunts, one born in Gilead and one living in neighbouring Canada. While Aunt Lydia’s testimony shows what Gilead looks like from the insiders’ top echelons, theirs show how the system appears to a typical female citizen of Gilead and to an outsider, respectively. Atwood perceptively crafts their testimonies to fit their status: Lydia’s voice is mature, philosophical and cynical; Victoria’s is fresh and idealistic reflecting her aspiration to reform Gilead; while Jade’s reflects the attitude of a typical North American teenager rejecting all that Gilead represents. Eventually they are united in a plan to expose Gilead and bring about its end, spawning a hair-raising adventure that keeps the reader in suspense. “The Testaments” does answer many questions about the aftermath of the first novel, but also raises new questions.

Obviously, Atwood set out to warn against dictatorial regimes and fanaticism of all types. The novel graphically illustrates how the oppression of women poisons all spheres of society, warping men as well. It also shows how women’s complicity in their own oppression and rivalry with other women make their suppression easier. With their obsession about falling birth rates and the increasing number of deformed babies (due largely to unacknowledged environmental degradation), the Gilead Commanders resemble various white nationalist groups now on the rise in the West, especially the US. While the focus is on gender discrimination, “The Testaments” is a powerful argument against all types of discrimination. It also touches on the international issues of refugees, rampant consumerism and the environment, hinting at factors that can pave the way for dramatic, anti-democratic “solutions”.

But Atwood’s book is more than a warning. It is an erudite, beautifully written treatise on the power of a mother’s love, and also on how love and acceptance of differences can unite people who are not kin but who share common values. Like many other previous dystopian novels, she also highlights the importance of reading and books.

Coronavirus hopes and fears centre on 'immunity'

By - May 30,2020 - Last updated at May 30,2020

People walk in the Ramblas of Barcelona on March 13 (AFP Josep Lago)

PARIS — Could exposure to the coronaviruses that cause the common cold help protect against COVID-19? Is herd immunity closer than previously thought?

As nations lift lockdowns and experts worry about a potential second peak in cases, our ability to ward off infection is one of the hottest topics of scientific debate.

Ever since it became apparent that children were less vulnerable to COVID-19 early in the pandemic, scientists have speculated that the regular spread of benign viruses in places like schools could have bolstered their immune response to the latest coronavirus.

Now the idea of "cross immunity" among the broader population is gaining some ground.

In a recent post on Twitter, Francois Balloux of University College London noted an "intriguing" lack of an immediate resurgence in COVID-19 cases following the easing of lockdowns in several countries.

Among the possible explanations, he noted, were seasonality and enduring social distancing practices.

But he posited a "wilder" hypothesis as well — that a "proportion of the population might have pre-existing immunity to #SARSCoV2, potentially due to prior exposure to 'common cold' coronaviruses".

Balloux said that might explain issues like cases where there is no transmission between spouses.

Earlier this month, an American study in the journal Cell suggested between 40 and 60 per cent of the population could be immunised against COVID-19 without ever being exposed to it.

Researchers put this down to the action of protective cells, known as T lymphocytes, that had been activated by other coronaviruses responsible for colds.

But authors Alessandro Sette and Shane Crotty, of La Jolla Institute for Immunology, cautioned that the research did not suggest the epidemic was running out of steam.

"Clearly some individuals are more susceptible to the disease than others; after being infected some individuals have severe clinical symptoms and might even die, while others might show very little in terms of clinical symptoms," they told AFP by email.

"Our study suggests that preexisting immunity might be one of the factors to be considered; but at this point is simply an hypothesis that needs to be addressed with further experiments."

 

'Jury out'

 

The World Health Organisation has also expressed caution over the issue.

"There is certainly some evidence with regard to T cells, that if you have a previous coronavirus infection you may be able to mount a more rapid response to COVID-19," said the WHO's Michael Ryan at a press conference this week.

"But there's no empirical evidence that previous coronavirus infections protect you from infection with COVID-19. The jury is still very much out on that," he added.

However, Ryan said it was an encouraging sign for the development of vaccines.

"It gives us hope that we are getting the kinds of immune responses that may be helpful to long-term protection," he said.

- New waves? -

Another uncertainty is whether everyone is equally vulnerable to catching COVID-19. 

A growing number of scientists think maybe not, raising questions over assumptions for what is known as herd immunity.

Gabriela Gomes, a researcher at the Liverpool School of Tropical Medicine, told AFP that it was wrong to assume that one person is as susceptible to the virus as another, or as exposed.

"We know little about the factors which underlie this individual variation. It could be cross-immunity with other coronaviruses, but it could also be other microbes, genetics, age, behaviour, and most likely a combination of many factors," she said.

In theory this could explain why early estimates of the proportion of individuals who have been infected by the new coronavirus have been lower than expected — at around 5 to 10 per cent of the total population in several countries.

It could also mean a lower threshold for herd immunity — when a sufficient part of the population has caught the virus, starving it of new hosts to spread to and thereby stopping the epidemic.

This threshold, commonly accepted as around 60 to 70 per cent of the population infected, is what Sweden hoped to achieve by deciding against a strict lockdown.

But Gomes said that mathematical models on herd immunity often "ignore individual variation".

According to a study she co-authored, which has not yet been peer reviewed, the threshold might be reached when just 10 to 20 per cent of the population has been infected.

Gomes said her research, which simulated the lifting of social distancing measures over the next six to 12 months, suggested that even if countries that had been severely affected are "closer to herd immunity", they would still see more localised outbreaks.

There could also be "what may seem like a second wave in those countries that have been less affected so far".

At the Pitie-Salpetriere hospital in Paris, professor of emergency medicine Yonathan Freund has noticed a sharp drop in the number of infections among doctors compared with the start of the epidemic.

"This is pure speculation but it could mean that people have natural or acquired immunity," he told AFP.

It is giving him confidence.

With infections staying low three weeks after France lifted its strict lockdown measures, he thinks that could mean "the second wave is not coming and probably will not happen" in the country.

By Paul Ricard

Maybe a few movies more? Clint Eastwood turns 90

By - May 30,2020 - Last updated at May 30,2020

Actor and director Clint Eastwood (AFP photo)

LOS ANGELES — Movie legend Clint Eastwood turns 90 on Sunday, but don't count on the famously stoic and hard-working star of "A Fistful of Dollars" and "Dirty Harry" hanging up his cowboy boots just yet.

The multiple Oscar-winning actor-turned-director, who churned out nine films in his 80s, has expressed no desire to retire ahead of the milestone — and in any case, he's not a fan of birthdays.

"We're just going to do a family thing — very, very calm, very mellow," his 34-year-old actor son Scott told "Access Hollywood."

"We'll sneak a cake in there, definitely. He probably won't like it."

Eastwood, born in 1930, has enjoyed a career spanning seven decades and more than 50 films. 

He last trod the Hollywood red carpet as recently as November, for his Olympic bombing biopic "Richard Jewell." 

It was released to mixed reviews — and sparked a backlash over its fictional depiction of a real-life female journalist trading sex for FBI secrets.

But Eastwood's career has weathered greater controversy, from accusations of excessive violence in the spaghetti Western "Dollars" trilogy, fascism in "Dirty Harry" and warmongering in "American Sniper," to his portrayal of racism in "Gran Torino."

As well as Oscars for "Unforgiven" and "Million Dollar Baby," and a lifetime achievement Palme d'Or from the Cannes festival, Eastwood's back catalog also contains a few critically savaged flops. 

"I would like to think it rolls off his back... he's gotten beat up along the way pretty regularly," Variety senior vice president Tim Gray told AFP.

"I think he's going to keep working as long as he can... he seems to have a creative drive that keeps him going."

 

'Just wants to work'

 

Known on the Hollywood circuit as polite but reticent as far as small talk or personal details, Eastwood has hinted at future projects, but had not yet confirmed any plans before the coronavirus pandemic shut down all productions in March.

In a January interview with Britain's ITV , Eastwood indicated he was still enjoying plying his trade.

"I like doing it, it's nice to be able to have a paying job," he told "This Morning."

"I like being in films, I like making films and I started directing films because I thought one day I'm going to look up on screen and say, 'That's enough, Eastwood — you'd better do something else.'"

In other interviews, he has expressed confusion as to why luminaries such as Billy Wilder and Frank Capra quit the business at a younger age, and spoken of his desire to keep working as long as he finds projects that are "worth studying."

Despite previously announcing his retirement from acting after 2008's "Gran Torino," Eastwood returned in front of camera four years later in "Trouble with the Curve," and again in 2018's "The Mule."

"He's pretty unpredictable," said Gray, adding: "I get the feeling now, he does what he wants to do."

As well as continuing to oversee his Malpaso Productions, Eastwood — a former mayor of Carmel, California — remains politically engaged, endorsing Michael Bloomberg's doomed presidential run earlier this year.

And as a father of eight children and a grandfather many times over, Eastwood will likely have his hands full Sunday — even if he isn't asking anyone to "make my day."

"He probably won't even want us to acknowledge it. He hates his birthday," daughter Alison told Closer late last year.

"I think he just wants to work and enjoy his life but I don't think he wants to celebrate it... So we'll see."

 

By Andrew Marszal

Dortmund, Favre facing tough questions after Bayern's 'big step'

By - May 28,2020 - Last updated at May 28,2020

Bayern Munich's German forward Thomas Mueller runs with the ball during their German first division Bundesliga football match against Borussia Dortmund on Tuesday in Dortmund, Germany (AFP photo by Federico Gambarini)

BERLIN — Borussia Dortmund visit bottom side Paderborn on Sunday with uncertainty surrounding the future of coach Lucien Favre after Tuesday's 1-0 defeat by Bayern Munich left their Bundesliga title dreams in tatters.

Favre and Dortmund were forced to deny rumours that he is set to resign, and face Paderborn attempting to at least keep some pressure on reigning champions Bayern, who sit seven points clear with six matches remaining.

Second-placed Dortmund may also have to make do without Erling Braut Haaland, after the teenage sensation was injured against Bayern, reportedly in an accidental collision with the referee.

Swiss Favre was forced to clarify comments made on Tuesday when he said he would "talk about it [his future] in a few weeks", saying the following day that he was not "giving up at all".

Several German newspapers have suggested Favre is set to leave at the end of the season, with Niko Kovac, who was sacked by Bayern last year, reported to be his likely successor.

"We are certainly not having a coaching debate," Dortmund sporting director Michael Zorc insisted to Sport1.

"Lucien must have expressed himself misleadingly in a moment immediately after the game."

Barring an unlikely late-season collapse from Bayern, it will be the second straight season that Favre's Dortmund have pushed their rivals close in the title race before ultimately coming up short.

Dortmund led for much of the campaign last term but stumbled late to finish two points off the pace.

"We said before the season that we wanted to play for the title again," added Zorc.

"We didn't manage to be better than Bayern. Now we can be disappointed, take a deep breath, and then set a new goal for Sunday. Full focus is on second place."

Dortmund will be confident of getting back on track against a Paderborn side who are rooted to the foot of the table, eight points adrift of the relegation play-off spot, despite three consecutive draws since the Bundesliga resumed following the coronavirus lockdown.

"We mustn't talk of a miracle because there are still 18 points to be won," said Paderborn coach Steffen Baumgart.

"As long as it's still mathematically possible we have to give it everything we've got."

 

Bayern's 'big step'

 

Bayern are now firmly on track for a record-extending eighth straight title and on Saturday host a Fortuna Duesseldorf side who boosted their survival hopes with a 2-1 midweek win against freefalling Schalke.

"We set out to take a big step [against Dortmund]. We succeeded. We showed a lot of determination," said Bayern coach Hansi Flick.

Duesseldorf, who occupy the relegation play-off spot, are five points clear of second-bottom Werder Bremen, although the four-time Bundesliga champions have a game in hand.

Bremen, who have only spent one season out of the top flight since the Bundesliga's formation in 1963, visit Schalke on Saturday.

Schalke coach David Wagner is under pressure after his side threw away their European hopes with a 10-match winless run, including three straight defeats since the restart of the season.

Dortmund will need Jadon Sancho to be back at his best on Sunday, with Haaland's injury leaving them without a recognised out-and-out striker.

English winger Sancho is yet to start a game since the restart after his own fitness problems, but has featured as a substitute in all three matches.

The 20-year-old has scored 17 goals in all competitions this season.

Virus screening: 'Grease' draws crowds at Madrid drive-in cinema

By - May 28,2020 - Last updated at May 28,2020

Madrid Race reopened its doors with a screening of the 1978 hit musical 'Grease' (AFP photo)

MADRID — For many, it was a long-awaited chance to feel normal again, sitting in their cars belting out "Summer Nights" at Madrid's drive-in cinema on a rare night out after a 10-week lockdown.

It's opening night at this 1950s-themed venue and as the sunsets, vehicles begin pulling into the huge car park, ushers ensuring each is carefully positioned several metres apart. 

With cinemas emptied across the world because of the pandemic, drive-in screens have seen a resurgence in popularity, offering those who've been cooped up at home for months a safe way to go out. 

Two days after the Spanish capital finally began to emerge from one of the most restrictive lockdowns in the world, the Madrid Race reopened its doors with a screening of the 1978 hit musical "Grease".

"We are the safest entertainment place in Madrid. It seems like drive-in cinema was made for a time like this," Madrid Race co-founder Cristina Porta told AFP, saying tickets for the month sold out in one day. 

For the venue, the epidemic and the resulting restrictions have opened a whole new business opportunity. 

"We've already got seven concerts booked and we're going to do theatre, masses, comedy, monologues and a bit of everything," she told AFP. 

"This summer, there's going to be a lot more than just cinema. There will be a lot of action and a lot of rock and roll."

 

'Your car like your home'

 

As night falls, the lights come on at the chrome metal diner, the "corn truck" is churning out buckets of popcorn and beer is flowing at the bar as staff in gloves and visors serve the growing crowd as they wait for the film to start.

"We came a few years ago and we liked it so we thought it would be a safe option," says 22-year-old Belen Perez who has come with her flatmate after finishing teacher training school.

On a normal night, there would be space for 375 cars but with Madrid only just reopening after suffering the brunt of an epidemic which in Spain claimed over 27,000 lives, they have limited entries to 100.

For now, the diner is closed to the public and tables are well-spaced at the bar terrace with customers able to order food through an app, with waiters delivering it to their car within 10 minutes.

"At the end of the day, your car is an extension of your home," says Porta.

"With these measures, it's enough to ensure there's zero risk of infection."

 

'Great safe entertainment'

 

And cinemagoers agree.

"Everyone has their own private space, there aren't many surfaces where you could pick up infection because during the film, no-one gets out of their car and if you want to order food you can do that online," agrees Perez. 

"It's a great way of being entertained safely."

For many, it's the first time they've been to a drive in, watching the film through their windscreen and hearing the soundtrack through a frequency on the car radio. 

"To be honest, it feels safer than most other things, even doing your daily shopping," said 28-year-old Daniel Martin, an aeronautical engineer. 

"I'm grateful to be here, even though you're a bit enclosed. At least we're socialising a bit even though we're separated, and that's something," he told AFP.

"Although we've seen the film more than 10 times, seeing it like this is something new. We've never been to a drive-in cinema before, so we're killing two birds with one stone!"

By Hazel Ward 

Chiptalk: Every second counts

By - May 28,2020 - Last updated at May 28,2020

Photo courtesy of innovationessence.com

Imagine making it from Amman to Aqaba with your car in one hour instead of the usual four. That’s the kind of speed improvement SSD (solid state drive) disc storage technology has brought us in the last few years, compared to HDD, the older, more traditional and mechanical hard disk drive models.

If SSD has already been widely adopted in the new laptop and desktop computers, till now the drives have been mainly installed inside the computers. Recently, however, manufacturers have started making and selling external USB SSDs, as a gradual move towards replacing HDD in mobile-external technology as well.

External USB disks are very popular and widely used to make additional safety copies of large amounts of data, or to transfer files between computers and users, in a reliable way, via a USB cabled connection. One of the most interesting SSD external USB models is SanDisk Extreme Pro. The portable unit will move 1.2 GB in two seconds flat. This is the approximate equivalent size of one hour of high-definition video, 150 MP3 songs or as many very large hi-res photos.

Already a regular, steady and known trend in the field of IT, the demand for “constantly more and faster” in every aspect of dealing with computers and the Internet has been exacerbated even further by the COVID-19 crisis, with each and every one looking for the best possible IT performance, be it offline or online, local or remote.

The demand is multidirectional. Of course, faster and more reliable Internet is the main issue here. Higher definition webcams, larger screens, better microphones and speakers and more cloud storage are also on the list of the very much sought-after items.

Having contacted three of the main computer shops in Amman, they confirmed that sales have been booming since citizens were allowed to go out again and take their car for shopping, thanks to the alternating odd-even traffic rule. They said that their main difficulty at present was importing and receiving enough models and quantity of goods to satisfy the demand. This is particularly obvious in sales of webcams, external USB discs, and USB charging portable battery banks.

Not surprisingly, and despite the apparent difficulty to get back to work “normally” in many a sector, Jordanian software development companies that deal with online and mobile payments are not only doing very well, but also are looking to recruit more staff.

Another example of the kind of pressure that is put on IT is the fact that most people now do not turn off their computer at night anymore, but put it in “sleep” mode instead, being able this way to resume using it instantly anytime they need to, day or night. IT professionals and heavy users had already adopted the sleep mode long ago. Until last March they were a minority. Now they are the majority.

Waiting two to five minutes (in some extreme cases…) to have your computer up and running in the morning was something you could live with. Now these minutes seem like an eternity. A few seconds is all you can afford or accept to wait.

In that line, it is worth noting that the newest models of laptops and when fitted with the above mentioned SSD discs, can be powered on from total shut off (i.e. not awoken from sleep mode) and get ready for you significantly faster than their older counterparts. They can do it a few seconds indeed, as if resuming from sleep mode for older models.

Yes, today’s life with computers and the web is about precious seconds and even fractions of a second in some cases.

Scientists unravel secrets from the faults in our genes

May 27,2020 - Last updated at May 27,2020

The genome is like the human instruction manual where words are genes and letters our DNA (AFP photo by Robyn Beck)

TOKYO — Imagine the body's instruction manual, the genome: here words are genes, letters are DNA, and the equivalent of typos can have disastrous consequences.

In recent years, scientists have grown increasingly fluent in the language of genome, but much remains mysterious, including the function of many of our genes.

Discovering what these genes are for, and how they work, is key to understanding what happens when they malfunction, causing disease and sometimes death.

Now a group of scientists is harnessing a massive database of genetic information from over 140,000 people to better understand which of our genes are important, and how we might better target medicines to treat genetic disease.

The database itself is something of a landmark. Known as the Genome Aggregation Database or gnomAD, it contains over 15,000 whole genome sequences — the equivalent of a full-length instruction manual — and over 125,000 whole exome sequences, akin to key points in the set of guidelines for the human body.

In seven papers published Wednesday in the journals Nature, Nature Communications and Nature Medicine, scientists combed through gnomAD data, focusing on a type of spelling error that effectively breaks the gene.

We all have some of these errors, known as loss-of-function variants, in our genome. But in most cases, they switch off or break a gene without ill-effect. We might end up with a diminished sense of smell, for example, but otherwise be healthy.

But when these mistakes occur in more important genes, they can result in serious illness.

Finding drug targets

People with these variants in important genes often don't pass them on because they die young or can't have children. 

That means scientists can search a giant dataset like gnomAD, looking for genes that have fewer variants than expected.

They can extrapolate that these genes must be important to our health, because variants in them have not been passed down due to natural selection.

"With 144,000 people we start to have big enough numbers that if we don't see loss-of-function variants in a particular gene that tells us that people carrying broken copies of this gene are being lost from the population, probably as a result of severe genetic disease," said Daniel MacArthur, who led the gnomAD project.

"We can't tell exactly what that disease is, but this tells us that this particular gene is likely to be important in some way," added MacArthur, senior author on six of the seven papers, who carried out the research at Harvard and MIT's Broad Institute.

Knowing which genes are important in disease not only offers targets for new drugs, but can also suggest whether a new treatment will be safe.

That was the focus of research by Eric Vallabh Minikel, who is studying a rare illness called prion disease at the Broad Institute.

The research is personal for Minikel. His mother-in-law died from the disease and his wife, a fellow scientist, carries a genetic mutation that means she is likely to develop it too.

He and his wife want to find a drug that prevents the disease, and examining naturally occurring gene inactivation offers insights into what side effects such a new treatment might have.

"The effects of DNA changes that inactivate a gene can help to predict what might happen if we treated people with a drug to target that gene," he told AFP.

Need for bigger datasets

In a similar vein, another team used the data to predict whether switching off a gene associated with Parkinson's might cause side effects. 

They found genomes where that gene was naturally switched off by loss-of-function variants, and in the majority of cases found this caused no harmful health effects.

That could suggest a drug targeting the gene might protect against Parkinson's, though the researchers cautioned significant further work is needed.

MacArthur, who is now director of the Garvan Institute's Centre for Population Genomics, said much bigger datasets than gnomAD are needed for further breakthroughs, potentially involving hundreds of millions of people and information on their health.

"We need that type of information... to get to the point where we can really start to fully understand the impact of variation in all genes in the genome on human disease risk."

By Sara Hussein

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