LOS ANGELES — Deadpool might not consider himself a superhero, but its latest installment is off to a powerful start.

The Marvel Comics film from 20th Century Fox debuted in North American with $125.5 million in 4,349 locations. That was not enough to match the debut of its predecessor, 2016’s “Deadpool”, which had the biggest opening ever for an R-rated film with $132.4 million. The Ryan Reynolds-starrer bowed overseas with $174.6 million for a global weekend total of $300.1 million.

Although it debuted under estimates, “Deadpool 2’s” launch was nothing to complain about. It still secured the second-best opening for an R-rated film, as well as the third-biggest debut of the year behind Marvel blockbusters “Avengers: Infinity War” and “Black Panther”. It also secured Fox its second-highest opening weekend in history.

The sequel is still boasting a promising critical consensus, with an 84 per cent Rotten Tomatoes rating and an A CinemaScore.

“Deadpool 2’s” strong debut is a testament to Reynolds, according to Fox’s president of domestic distribution Chris Aronson.

“I just can’t say enough about him,” Aronson said. “Not just the character, but promoting it. I feel great about this opening.”

Its opening was enough to crush “Avengers: Infinity War’s” reign on the domestic box office. After securing the No. 1 spot for three weeks, the Disney and Marvel superhero tentpole dropped to second place. Its fourth weekend haul was still impressive, reeling in $29.5 million from 4,002 screens. “Infinity War’s” domestic tally currently sits at $595.9 million.

“Infinity War” was followed by Paramount Pictures’ new release, “Book Club”. The romantic comedy — starring Diane Keaton, Jane Fonda, Candice Bergen, and Mary Steenburgen — came in slightly ahead of expectations, earning $13.6 million on 2,781 screens.

The weekend’s other newcomer, Global Road Entertainment’s “Show Dogs”, landed in sixth place, only digging up $6 million from 3,212 locations. The family-friendly comedy garnered an A CinemaScore. Its Rotten Tomatoes critical score did not fare quite as well, averaging a 26 per cent.

Rounding out the top five are two film’s sophomore frames. Warner Bros.’ “Life of the Party” rallied in $7.6 million from 3,656 locations. Domestically, it has made $30.9 million. Universal’s “Breaking In” secured $6.8 million on 2,537 screens. In two weeks, it is earned $28.8 million.

“Overboard” ($4.6 million), “A Quiet Place” ($3.9 million), “Rampage” ($1.6 million) and “I Feel Pretty” ($1.3 million) rounded off the top 10.

In the specialty market, Focus Features’ “Pope Francis — A Man of His Word” opened with $480,000 on 346 screens for a per screen average of $1,389.

“RBG”, the documentary on Supreme Court Justice Ruth Bader Ginsburg, is still holding strong. In its third weekend, it expanded to 375 locations for a three-day total of $1.28 million. That is a per screen average of $3,413. Magnolia Pictures and Participant Media co-produced the film with Storyville Films and CNN Films.

Thanks to a trio of superhero powerhouses, the domestic box office is up 6.3 per cent from 2017, according to comScore. The weekend-to-date is up a staggering 62.9 per cent, compared to 2017 when “Alien: Covenant” was the No. 1 film.

“A crowded powerhouse of a mid-May weekend benefitted from a very diverse line-up of newcomers to appeal to almost every taste and demographic,” Paul Dergarabedian, box office analysis at comScore, said.